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KMID : 0978920000010010045
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Korean Journal of Clinical Geriatrics
2000 Volume.1 No. 1 p.45 ~ p.52
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Efficacy and Safety of Amezinium methylsulfate for Orthostatic Hypotension in the Elderly
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Lee Sang-Hyun
Bae Chul-Young
Cho Choo-Yon
Choi Kyu-Dong
Kim Ja-Young
Oh Han-Jin
Lee Sang-Yeoup
Park Joo-Sung
Yoo Hee-Tak
Won Chang-Won
Cho Kyung-Hee
Kim Se-In
Baik Ki-Joo
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Abstract
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Background: Orthostatic hypotension is common condition in the elderly, but choice to treat it pharmacologically 잉 limited because of e지:iected side effects. Arnezinium metilsulfate is an indirectly acting symathomimetic drug, which affects postganglionic sym맹thetic neurons, selectively inhibiting both intraneural monoamine o잉dase and reuptake of norepinephrine. The purpose of this study was to assess the efficacy of amezinium for orthostatic hypotension in the elderly.
Methods: A total of 100 patients aged 60 years or older with orthostatic hypotension participated in in this multicenter study. The treatment group (n =41) received amezinium 10mg bid for two weeks and was given a patient education brochure about orthostatic hypotension. The control group received only the patient education brochure. We evaluated the patients blood pressure, p띠se rate at supine, one and three minutes after standing. Assessments of orthostatic symptoms and laboratory examination were done before and after intervention.
Results : In patients with orthostatic symptoms, amezinium treated patients showed improvements in dizziness (60.0%), palpitation (47.1%), nausea (56.3%) whereas the control group reported improvements in dizziness (42.9%), palpit:ation (25.0%), nausea (30.0%), without statistical significance. In the global symptom evaluation by the investigator, the amezinium group had more improvements compared to the control group (p < 0.001). Standing systolic and diastolic blood pressure after treatment with amezinium was significantly increased without c따nges in supine blood pressure and pulse rate. Only st:anding diastolic blo여 pressure in the patient educated contr이 group was increased. We calculated net differences of orthost:atic changes of blood pressure and pulse rate after intervention. The differences of st:anding change of blood pressure in the amezinium group were greater than those in the control group. Thpecially the difference in diastolic blo여 pressure at 3 minutes after st:an이ng was significant.
Conclusion: This study indicates that amezinium is efficacious and safe in the treatment of orthost:atic hypotension in the elderly’ without change of resting blood pressure and pulse rate.
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KEYWORD
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orthostatic hypotension, aged, blood pressure, amezinium
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